Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools

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dc.contributor.author Castberg, F.C.
dc.contributor.author Sarbah, E.W.
dc.contributor.author Koram, K.A.
dc.contributor.author Opoku, N.
dc.contributor.author Ofori, M.F.
dc.contributor.author Styrishave, B.
dc.contributor.author Hviid, L.
dc.contributor.author Kurtzhals, J.A.L.
dc.date.accessioned 2019-06-13T10:23:52Z
dc.date.available 2019-06-13T10:23:52Z
dc.date.issued 2018-12
dc.identifier.other https://doi.org/10.1186/s12936-018-2609-6
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/30749
dc.description.abstract Background Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested. Methods Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Children, who were transfused or received iron supplementation in the follow-up period, were excluded, and iron stores were considered to be stable throughout. Ferritin levels 6 weeks after admission were used as a reference for admission iron status and compared with iron markers at different time points. Results There were long-term perturbations in iron markers during convalescence from acute malaria. None of the tested iron parameters, including FGF23, were independent of inflammation. CRP and AGP normalized faster than ferritin after malaria episodes. Conclusion Malaria may bias epidemiological studies based on inflammation-dependent iron markers. Better markers of iron status during and after inflammation are needed in order to test strategies for iron supplementation in populations at risk of malaria. en_US
dc.language.iso en en_US
dc.publisher Malaria Journal en_US
dc.subject Iron deficiency en_US
dc.subject Malaria en_US
dc.subject Hepcidin en_US
dc.subject FGF23 en_US
dc.subject Ferritin en_US
dc.title Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools en_US
dc.type Article en_US


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  • Parasitology Department [244]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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