Human Vδ1+ T Cells in the Immune Response to Plasmodium falciparum Infection

Show simple item record Hviid, L. Smith-Togobo, C. Willcox, B.E. 2019-05-24T08:47:12Z 2019-05-24T08:47:12Z 2019-02
dc.identifier.other DOI: 10.3389/fimmu.2019.00259
dc.description.abstract Naturally acquired protective immunity to Plasmodium falciparum malaria is mainly antibody-mediated. However, other cells of the innate and adaptive immune system also play important roles. These include so-called unconventional T cells, which express a γδ T-cell receptor (TCR) rather than the αβ TCR expressed by the majority of T cells—the conventional T cells. The γδ T-cell compartment can be divided into distinct subsets. One expresses a TCR involving Vγ9 and Vδ2, while another major subset uses instead a TCR composed of Vδ1 paired with one of several types of γ chains. The former of these subsets uses a largely semi-invariant TCR repertoire and responds in an innate-like fashion to pyrophosphate antigens generated by various stressed host cells and infectious pathogens, including P. falciparum. In this short review, we focus instead on the Vδ1 subset, which appears to have a more adaptive immunobiology, but which has been much less studied in general and in malaria in particular. We discuss the evidence that Vδ1+ cells do indeed play a role in malaria and speculate on the function and specificity of this cell type, which is increasingly attracting the attention of immunologists. en_US
dc.language.iso en en_US
dc.publisher Frontiers in immunology en_US
dc.subject Gamma-delta (γ/δ) T lymphocytes en_US
dc.subject Vdelta1 gamma delta T cells en_US
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Innate immunity en_US
dc.subject Acquired immunity en_US
dc.subject Immune regulation en_US
dc.title Human Vδ1+ T Cells in the Immune Response to Plasmodium falciparum Infection en_US
dc.type Article en_US

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