TB-diabetes co-morbidity in Ghana: The importance of Mycobacterium africanum infection

Show simple item record

dc.contributor.author Asante-Poku, A.
dc.contributor.author Asare, P.
dc.contributor.author Baddoo, N.A.
dc.contributor.author Forson, A.
dc.contributor.author Klevor, P.
dc.contributor.author Otchere, I.D.
dc.contributor.author Aboagye, S.Y.
dc.contributor.author Osei-Wusu, S.et.al
dc.date.accessioned 2019-05-21T11:40:16Z
dc.date.available 2019-05-21T11:40:16Z
dc.date.issued 2019-02
dc.identifier.citation Asante-Poku A, Asare P, Baddoo NA, Forson A, Klevor P, Otchere ID, et al. (2019) TB-diabetes co-morbidity in Ghana: The importance of Mycobacterium africanum infection. PLoS ONE 14(2): e0211822. https://doi.org/10.1371/journal.pone.0211822 en_US
dc.identifier.other https://doi.org/10.1371/journal.pone.0211822
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/30140
dc.description.abstract Background: Diabetes Mellitus (DM) is a known risk factor for tuberculosis (TB) but little is known on TB-Diabetes Mellitus (TBDM) co-morbidity in Sub-Saharan Africa. Methods: Consecutive TB cases registered at a tertiary facility in Ghana were recruited from September 2012 to April 2016 and screened for DM using random blood glucose and glycated hemoglobin (HbA1c) level. TB patients were tested for other clinical parameters including HIV co-infection and TB lesion location. Mycobacterial isolates obtained from collected sputum samples were characterized by standard methods. Associations between TBDM patients' epidemiological as well as microbiological variables were assessed. Results: The prevalence of DM at time of diagnosis among 2990 enrolled TB cases was 9.4% (282/2990). TBDM cases were significantly associated with weight loss, poor appetite, night sweat and fatigue (p<0.001) and were more likely (p<0.001) to have lower lung cavitation 85.8% (242/282) compared to TB Non-Diabetic (TBNDM) patients 3.3% (90/2708). We observed 22.3% (63/282) treatment failures among TBDM patients compared to 3.8% (102/2708) among TBNDM patients (p<0.001). We found no significant difference in the TBDM burden attributed by M. tuberculosis sensu stricto (Mtbss) and Mycobacterium africanum (Maf) and (Mtbss; 176/1836, 9.6% and Maf; 53/468, 11.3%, p = 0.2612). We found that diabetic individuals were suggestively likely to present with TB caused by M. africanum Lineage 6 as opposed to Mtbss (odds ratio (OR) = 1.52; 95% confidence interval (CI): 0.92-2.42, p = 0.072). Conclusion: Our findings confirms the importance of screening for diabetes during TB diagnosis and highlights the association between genetic diversity and diabetes. in Ghana. en_US
dc.language.iso en en_US
dc.publisher PLoS ONE en_US
dc.title TB-diabetes co-morbidity in Ghana: The importance of Mycobacterium africanum infection en_US
dc.type Article en_US

Files in this item

This item appears in the following Collection(s)

  • Bacteriology Department [105]
    The Bacteriology Department aims to improve the quality of life first for Ghanaians and the world at large by conducting research into bacterial diseases of public health importance to Ghana and globally. In addition to working on enteric pathogens and sexually transmitted diseases, the department’s current main focus is on the two most important mycobacterial diseases of public health importance to Ghana, namely Buruli ulcer (BU) and tuberculosis (TB).

Show simple item record

Search UGSpace


My Account