Latent TB Infection (LTBI) – Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground

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dc.contributor.author Rao, M.
dc.contributor.author Ippolito, G.
dc.contributor.author Mfinanga, S.
dc.contributor.author Ntoumi, F.
dc.contributor.author Yeboah-Manu, D.
dc.contributor.author Vilaplana, C.
dc.contributor.author Zumla, A.
dc.contributor.author Maeurer, M.
dc.date.accessioned 2019-05-21T10:04:21Z
dc.date.available 2019-05-21T10:04:21Z
dc.date.issued 2019-02
dc.identifier.other https://doi.org/10.1016/j.ijid.2019.02.035
dc.identifier.other Volume 80, Supplement, Pages S58-S61
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/30132
dc.description.abstract Latent tuberculosis infection (LTBI) is established in over 90% of persons infected with Mycobacterium tuberculosis (Mtb), from whom new active TB cases will arise. Understanding the spatio-temporal dynamics of host immune responses in LTBI granulomas is essential to designing effective post-exposure therapies that inhibit progression to TB. Information arising from cancer studies and other modalities – where local chronic inflammation leads to immunopathology – can help provide insights into the biological pathways at play in LTBI granulomas. Translational studies using patient material as well as LTBI+ donor-derived tissue samples are instrumental in understanding the various components of granuloma dynamics, immunological landscapes therein and how this could help to identify therapeutic targets. Deep sequencing technologies may aid to decipher the genetic changes in lung granuloma and blood samples from LTBI+ individuals associated with progression to active TB disease. This may lead to advancement of development of targeted Host-Directed Therapies (HDTs) and their evaluation as adjunct TB therapies for improving treatment outcomes for LTBI and pulmonary TB. Keywords: latent tuberculosis infection, granuloma, mutations, immune landscape, host-directed therapies en_US
dc.language.iso en en_US
dc.publisher International Journal of Infectious Diseases en_US
dc.subject Latent tuberculosis infection en_US
dc.subject Granuloma en_US
dc.subject Mutations en_US
dc.subject Immune landscape en_US
dc.subject Host-directed therapies en_US
dc.title Latent TB Infection (LTBI) – Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground en_US
dc.type Article en_US


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  • Bacteriology Department [108]
    The Bacteriology Department aims to improve the quality of life first for Ghanaians and the world at large by conducting research into bacterial diseases of public health importance to Ghana and globally. In addition to working on enteric pathogens and sexually transmitted diseases, the department’s current main focus is on the two most important mycobacterial diseases of public health importance to Ghana, namely Buruli ulcer (BU) and tuberculosis (TB).

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