Characterization of Two New Multidrug-Resistant Strains of Mycobacterium smegmatis: Tools for Routine In Vitro Screening of Novel Anti-Mycobacterial Agents

Show simple item record

dc.contributor.author Arthur, P.K.
dc.contributor.author Amarh, V.
dc.contributor.author Cramer, P.
dc.contributor.author Arkaifie, G.B.
dc.contributor.author Blessie, E.J.S.
dc.contributor.author Fuseini, M.S.
dc.contributor.author Carilo, I.
dc.contributor.author Yeboah, R.
dc.contributor.author Asare, L.
dc.contributor.author Robertson, B.D.
dc.date.accessioned 2019-05-20T11:31:27Z
dc.date.available 2019-05-20T11:31:27Z
dc.date.issued 2019-01
dc.identifier.other DOI: 10.3390/antibiotics8010004
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/30119
dc.description.abstract Mycobacterium tuberculosis is a pathogen of global public health concern. This threat is exacerbated by the emergence of multidrug-resistant and extremely-drug-resistant strains of the pathogen. We have obtained two distinct clones of multidrug-resistant Mycobacterium smegmatis after gradual exposure of Mycobacterium smegmatis mc² 155 to increasing concentrations of erythromycin. The resulting resistant strains of Mycobacterium smegmatis exhibited robust viability in the presence of high concentrations of erythromycin and were found to be resistant to a wide range of other antimicrobials. They also displayed a unique growth phenotype in comparison to the parental drug-susceptible Mycobacterium smegmatis mc² 155, and a distinct colony morphology in the presence of cholesterol. We propose that these two multidrug-resistant clones of Mycobacterium smegmatis could be used as model organisms at the inceptive phase of routine in vitro screening of novel antimicrobial agents targeted against multidrug-resistant Mycobacterial tuberculosis. en_US
dc.language.iso en en_US
dc.publisher Antibiotics en_US
dc.subject Antibiotics en_US
dc.subject Antimicrobial resistance en_US
dc.subject Tuberculosis en_US
dc.subject Mycobacteria en_US
dc.title Characterization of Two New Multidrug-Resistant Strains of Mycobacterium smegmatis: Tools for Routine In Vitro Screening of Novel Anti-Mycobacterial Agents en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search UGSpace


Browse

My Account