Allergic characteristics of urban schoolchildren with atopic eczema in Ghana

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dc.contributor.author Hogewoning, A.A.
dc.contributor.author Larbi, I.A.
dc.contributor.author Addo, H.A.
dc.contributor.author Amoah, A.S.
dc.contributor.author Boakye, D.
dc.contributor.author Hartgers, F.
dc.contributor.author Yazdanbakhsh, M.
dc.contributor.author Van Ree, R.
dc.contributor.author Bouwes Bavinck, J.N.
dc.contributor.author Lavrijsen, A.P.M.
dc.date.accessioned 2019-04-30T10:46:12Z
dc.date.available 2019-04-30T10:46:12Z
dc.date.issued 2010-04
dc.identifier.other DOI: 10.1111/j.1468-3083.2010.03655.x
dc.identifier.other Vol. 24(12): pp 1406-12
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/29683
dc.description.abstract Background: Atopic eczema is an increasing clinical problem in Africa. Objective: To determine allergic characteristics and to identify possible risk factors for eczema among schoolchildren in an urbanized area in Ghana. Patients and methods: Schoolchildren aged 3-16 years with eczema were recruited. For each patient, one to three age- and sex-matched controls were selected. All children completed a questionnaire and were skin prick tested with a panel of allergens. Blood was drawn to determine the total and allergen-specific IgE. Conditional logistic regression models with the matching factors included in the model were used to calculate the odds ratios and to adjust for possible confounders. Results: A total of 52 children with eczema (27 boys and 25 girls) and 99 controls were included. Levels of total IgE were found to be 9.1 (1.1; 78.4) times more often elevated in children with eczema. This association was mainly driven by elevated IgE levels against cockroach antigen. Children with eczema were found to have 2.0 (0.87; 4.7) times more often positive skin prick tests (SPT), but this association diminished to 1.2 (0.40; 3.6) after adjustment for total IgE levels. Frequent washing with soap was identified as a risk factor for the development of eczema among these children. Conclusion: Schoolchildren with eczema in Ghana were characterized by elevated IgE levels especially against cockroach antigen. The association between eczema and positive SPT was much weaker suggesting immune hyporesponsiveness of the skin. After adjustment for IgE level, SPT were less suitable to distinguish children with and without eczema. © 2010 European Academy of Dermatology and Venereology. en_US
dc.language.iso en en_US
dc.publisher Journal of the European Academy of Dermatology and Venereology en_US
dc.subject Africa en_US
dc.subject Atopic dermatitis en_US
dc.subject Cockroach en_US
dc.subject Eczema en_US
dc.subject House dust mite en_US
dc.subject Immunoglobulin E en_US
dc.subject Skin prick tests en_US
dc.title Allergic characteristics of urban schoolchildren with atopic eczema in Ghana en_US
dc.type Article en_US


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  • Parasitology Department [240]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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