Out of Africa: What can be learned from the studies of allergic disorders in Africa and Africans?

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dc.contributor.author Obeng, B.B.
dc.contributor.author Hartgers, F.
dc.contributor.author Boakye, D.
dc.contributor.author Yazdanbakhsh, M.
dc.date.accessioned 2019-04-12T10:15:16Z
dc.date.available 2019-04-12T10:15:16Z
dc.date.issued 2008-10
dc.identifier.other doi: 10.1097/ACI.0b013e32830ebb70
dc.identifier.other Vol.8(5): pp 391-7
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/29194
dc.description.abstract Purpose of review Allergic diseases have only recently gained serious attention in Africa. This review discusses recent studies that have focused on allergy among Africans and people of African ancestry. Recent findings Time trend studies of the prevalence of allergies in Africa show a consistent increase over a period of 7-10 years. Recent studies have reported that the link between IgE, skin reactivity to allergens and allergic symptoms increases with increasing gross national income of the country. Association between helminth infections, and allergies seem contradictory, which may be attributed to differences in the length of infection and species studied. Importantly, researchers have identified an 'urban diet' component, which is associated with increased skin reactivity to allergens. Finally, whereas Africans in rural Africa seem to suffer less from allergies, people of African ancestry in affluent countries have higher prevalence and greater severity of allergic symptoms than natives of these host countries, raising important issues on genetic control of allergic diseases. Summary Mechanisms underlying the development of allergy are a complex interaction of genetic susceptibility and environmental exposures. Identification of specific environmental factors, mechanistic pathways and genetic risk factors in sufficiently powered studies will be necessary to better understand and control the allergic march in Africa and elsewhere. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins. en_US
dc.language.iso en en_US
dc.publisher Current Opinion in Allergy and Clinical Immunology en_US
dc.subject Africa en_US
dc.subject Allergy en_US
dc.subject Asthma en_US
dc.subject Environment en_US
dc.subject Epidemiology en_US
dc.subject Genetics en_US
dc.subject Infections en_US
dc.title Out of Africa: What can be learned from the studies of allergic disorders in Africa and Africans? en_US
dc.type Article en_US


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  • Parasitology Department [244]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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