Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans

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dc.contributor.author Etuaful, S.
dc.contributor.author Carbonnelle, B.
dc.contributor.author Grosset, J.
dc.contributor.author Lucas, S.
dc.contributor.author Horsfield, C.
dc.contributor.author Phillips, R.
dc.contributor.author Evans, M.
dc.contributor.author Ofori-Adjei, D.
dc.contributor.author Klustse, E.
dc.contributor.author Owusu-Boateng, J.et.al.
dc.date.accessioned 2019-03-20T11:15:02Z
dc.date.available 2019-03-20T11:15:02Z
dc.date.issued 2005-08
dc.identifier.issn DOI: 10.1128/AAC.49.8.3182-3186.2005
dc.identifier.other Vol. 49(8): pp 3182-6
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/28731
dc.description.abstract Mycobacterium ulcerans disease is common in some humid tropical areas, particularly in parts of West Africa, and current management is by surgical excision of skin lesions ranging from early nodules to extensive ulcers (Buruli ulcer). Antibiotic therapy would be more accessible to patients in areas of Buruli ulcer endemicity. We report a study of the efficacy of antibiotics in converting early lesions (nodules and plaques) from culture positive to culture negative. Lesions were excised either immediately or after treatment with rifampin orally at 10 mg/kg of body weight and streptomycin intramuscularly at 15 mg/kg of body weight daily for 2, 4, 8, or 12 weeks and examined by quantitative bacterial culture, PCR, and histopathology for M. ulcerons. Lesions were measured during treatment. Five lesions excised without antibiotic treatment and five lesions treated with antibiotics for 2 weeks were culture positive, whereas three lesions treated for 4 weeks, five treated for 8 weeks, and three treated for 12 weeks were culture negative. No lesions became enlarged during antibiotic treatment, and most became smaller. Treatment with rifampin and streptomycin for 4 weeks or more inhibited growth of M. ulcerons in human tissue, and it provides a basis for proceeding to a trial of antibiotic therapy as an alternative to surgery for early M. ulcerons disease. Copyright © 2005, American Society for Microbiology. All Rights Reserved. en_US
dc.language.iso en en_US
dc.publisher Antimicrobial Agents and Chemotherapy en_US
dc.subject Rifampin-streptomycin en_US
dc.subject Mycobacterium ulcerans en_US
dc.subject Buruli ulcer en_US
dc.title Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans en_US
dc.type Article en_US


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  • Electron Microscopy Department [69]
    The main research focus of the Electron Microscopy and Histopathology Department in the past 20 years has been in the areas of enteric diarrhoeas with special emphasis on rotavirus. Through its diarrhoea surveillance studies, the Department has helped to firmly establish rotaviruses as a major cause of diarrhoea in children, and document the circulation of unusual rotavirus genotypes in Ghana. The Department has also recently expanded its diagnostic repertoire to include the identification and characterization of noroviruses, astroviruses, and other enteric viruses.

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