Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

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dc.contributor.author Gyan, B.A.
dc.contributor.author Goka, B.
dc.contributor.author Cvetkovic, J.T.
dc.contributor.author Kurtzhals, J.L.
dc.contributor.author Adabayeri, V.
dc.contributor.author Perlmann, H.
dc.contributor.author Lefvert, A.-K.
dc.contributor.author Akanmori, B.D.
dc.contributor.author Troye-Blomberg, M.
dc.date.accessioned 2019-03-15T14:10:05Z
dc.date.available 2019-03-15T14:10:05Z
dc.date.issued 2004-10
dc.identifier.other https://doi.org/10.1111/j.1365-2249.2004.02590.x
dc.identifier.other Vol. 138(1): pp 145-50 ·
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/28643
dc.description.abstract Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and -590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0-0001, odds ratio (OR) = 8-7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria. en_US
dc.language.iso en en_US
dc.publisher Clinical and Experimental Immunology en_US
dc.subject Falciparum en_US
dc.subject IgE en_US
dc.subject IL-4 polymorphism en_US
dc.subject Pathogenesis en_US
dc.subject Plasmodium en_US
dc.subject Severe malaria en_US
dc.title Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children en_US
dc.type Article en_US


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  • Immunology Department [184]
    The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

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