Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis

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dc.contributor.author Lafond, K.E.
dc.contributor.author Ampofo, W.
dc.contributor.author Nair, H.
dc.contributor.author Rasooly, M.H.
dc.contributor.author Valente, F. et.al.
dc.date.accessioned 2019-02-19T13:18:58Z
dc.date.available 2019-02-19T13:18:58Z
dc.date.issued 2016-03
dc.identifier.citation Global Respiratory Hospitalizations—Influenza Proportion Positive (GRIPP) Working Group (2016). Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis. PLoS Medicine, 13(3), [e1001977]. https://doi.org/10.1371/journal.pmed.1001977 en_US
dc.identifier.other https://doi.org/10.1371/journal.pmed.1001977
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/27640
dc.description.abstract Background: The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide. Methods and Findings: We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group (<6 mo, <1 y, <2 y, <5 y, 5–17 y, and <18 y). We applied this proportion to global estimates of acute lower respiratory infection hospitalizations among children aged <1 y and <5 y, to obtain the number and per capita rate of influenza-associated hospitalizations by geographic region and socio-economic status. Influenza was associated with 10% (95% CI 8%–11%) of respiratory hospitalizations in children <18 y worldwide, ranging from 5% (95% CI 3%–7%) among children <6 mo to 16% (95% CI 14%–20%) among children 5–17 y. On average, we estimated that influenza results in approximately 374,000 (95% CI 264,000 to 539,000) hospitalizations in children <1 y—of which 228,000 (95% CI 150,000 to 344,000) occur in children <6 mo—and 870,000 (95% CI 610,000 to 1,237,000) hospitalizations in children <5 y annually. Influenza-associated hospitalization rates were more than three times higher in developing countries than in industrialized countries (150/100,000 children/year versus 48/100,000). However, differences in hospitalization practices between settings are an important limitation in interpreting these findings. Conclusions: Influenza is an important contributor to respiratory hospitalizations among young children worldwide. Increasing influenza vaccination coverage among young children and pregnant women could reduce this burden and protect infants <6 mo. © 2016, Public Library of Science. All Rights Reserved. en_US
dc.language.iso en en_US
dc.publisher PLoS Medicine en_US
dc.subject Influenza en_US
dc.subject Influenza viruses en_US
dc.subject Respiratory infections en_US
dc.subject Pediatric infections en_US
dc.title Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis en_US
dc.type Article en_US


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  • Virology Department [114]
    Most research activities involve the use of molecular methods such as regular PCR (PCR), quantitative PCR (Q-PCR), genomic sequence and analysis using different software, genetic engineering, probe hybridization techniques, biological and molecular cloning, evaluation of immune markers for laboratory diagnosis of infections, serological assays involving the use of rapid tests, ELISA-based evaluations and immunofluorescent assay techniques.

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