A High-Density Admixture Map for Disease Gene Discovery in African Americans

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dc.contributor.author Smith, M.W.
dc.contributor.author Patterson, N.
dc.contributor.author Lautenberger, J.A.
dc.contributor.author Truelove, A.L.
dc.contributor.author Poku, K.
dc.contributor.author O'Brien, S.J. et al.
dc.date.accessioned 2019-02-19T11:26:25Z
dc.date.available 2019-02-19T11:26:25Z
dc.date.issued 2004-05
dc.identifier.citation Smith, Michael et al. “A high-density admixture map for disease gene discovery in african americans.” American journal of human genetics 74 5 (2004): 1001-13 . en_US
dc.identifier.other Vol. 74(5): pp 1001–1013
dc.identifier.other doi: 10.1086/420856
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/27624
dc.description.abstract Admixture mapping (also known as “mapping by admixture linkage disequilibrium,” or MALD) provides a wayof localizing genes that cause disease, in admixed ethnic groups such as African Americans, with∼100 times fewermarkers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerfulscans with admixture mapping because the method requires a dense map of validated markers known to have largefrequency differences between Europeans and Africans. To create such a map, we screened through databasescontaining∼450,000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in Africanand European population samples. We experimentally confirmed the frequencies of the most promising SNPs in amultiethnic panel of unrelated samples and identified 3,011 as a MALD map (1.2 cM average spacing). We estimatethat this map is∼70% informative in differentiating African versus European origins of chromosomal segments.This map provides a practical and powerful tool, which is freely available without restriction, for screening fordisease genes in African American patient cohorts. The map is especially appropriate for those diseases that differin incidence between the parental African and European populations. en_US
dc.language.iso en en_US
dc.publisher The American Society of Human Genetics en_US
dc.subject Admixture map en_US
dc.subject Disease Gene Discovery en_US
dc.subject African Americans en_US
dc.title A High-Density Admixture Map for Disease Gene Discovery in African Americans en_US
dc.type Article en_US

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