Shrinkage of prostate and improved quality of life: Management of BPH patients with croton membranaceus ethanolic root extract

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dc.contributor.author Asare, G.A.
dc.contributor.author Afriyie, D.
dc.contributor.author Ngala, R.A.
dc.contributor.author Appiah, A.A.
dc.contributor.author Anang, Y.
dc.contributor.author Musah, I.
dc.contributor.author Adjei, S.
dc.contributor.author Bamfo-Quaicoe, K.
dc.contributor.author Sule, D.
dc.contributor.author Gyan, B.A.
dc.contributor.author Arhin, P.
dc.contributor.author Edoh, D.A.
dc.date.accessioned 2019-02-15T09:32:20Z
dc.date.available 2019-02-15T09:32:20Z
dc.date.issued 2015-02
dc.identifier.other http://dx.doi.org/10.1155/2015/365205
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/27548
dc.description.abstract Benign prostatic hyperplasia (BPH) is an enlargement of the prostate. The study aimed at validating the use of freeze-dried Croton membranaceus ethanolic root extract for BPH management. Thirty-three patients were observed before and after 3-month administration of 20 mg t.i.d orally. The International Prostate Symptom Score (IPSS), and the International Index of Erectile Function (IIEF) questionnaires were used. Total/free PSA (tPSA, fPSA), renal, liver function, lipid tests, and ultrasonographic imaging were performed. Thirty (30) patients (66 ± 11 years) completed the study. IPSS results showed 37% had severe, 40% moderate, and 23% mild symptoms before; 57% and 43% had moderate and mild symptoms, respectively, after treatment. IIED of patients' results showed 30% with severe, 40% moderate, 24% mild-moderate, 3% mild, and 3% no erectile dysfunction before treatment and 20% severe, 43% moderate, and 37% mild-moderate dysfunction, after treatment. Quality of life (QoL) improved (P = 0.001). Significant but non-pathological increases in total and indirect bilirubin as well as apolipoprotein A occurred. Mean tPSA reduced from 27.9 ± 19.0 to 16.2 ± 11.8 ng/mL (P = 0.002); fPSA from 6.1 ± 4.8 to 3.9 ± 2.9 ng/mL (P = 0.045); and prostate volume from 101.8 ± 41.3 to 54.5 ± 24.8 cm3 (P = 0.023). C. membranaceus shrinks the prostate and improves QoL. © 2015 George Awuku Asare et al. en_US
dc.language.iso en en_US
dc.publisher Evidence-based Complementary and Alternative Medicine en_US
dc.subject Shrinkage of prostate en_US
dc.subject Quality of life en_US
dc.subject BPH patients en_US
dc.subject Croton membranaceus en_US
dc.subject Ethanolic root extract en_US
dc.title Shrinkage of prostate and improved quality of life: Management of BPH patients with croton membranaceus ethanolic root extract en_US
dc.type Article en_US


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