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Title: Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection
Authors: Addae, M.M.
Komada, Y.
Zhang, X.
Sakurai, M.
Keywords: Apoptosis/*immunology
Case-Control Studies
Child, Preschool
Protein Kinase C/blood/immunology
Receptors, Interleukin-2
Tetradecanoylphorbol Acetate/pharmacology
Issue Date: 1995
Publisher: Acta Paediatrica Japonica
Citation: Addae, M. M., Komada, Y., Zhang, X. -., & Sakurai, M. (1995). Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection. Acta Paediatrica Japonica (Overseas Edition), 37(3), 308-314
Abstract: The phenotypic alterations associated with T cells during measles virus infection have been demonstrated and an attempt has been made to show programmed cell death (PCD) of T cells activated in vivo. During the acute phase of illness, activated T cells increased rapidly. Memory T cells (CD45RO+), especially CD8+ memory T cells also tend to increase. During the recovery phase, CD8+ T cells declined rapidly, and naive (CD45RA+) T cells increased in numbers. The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor (CD25) was suppressed. However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression. In addition, PCD of activated T cells from measles patients was induced in culture. After triggering of the T cell receptor-CD3 complex, cells became more susceptible to PCD. Interestingly, the addition of PMA could inhibit PCD of activated T cells. Taken together, these data suggest unresponsiveness and activation-induced cell death of T cells during the primary response to measles virus antigens, depending on the activation status of protein kinase C.
Appears in Collections:School of Allied Health Sciences

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