In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study

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dc.contributor.author Tekwu, E.W.
dc.contributor.author Bosompem, K.M.
dc.contributor.author Anyan, W.K.
dc.contributor.author Appiah-Opong, R.
dc.contributor.author Owusu, K.B.-A.
dc.contributor.author Tettey, M.D.
dc.contributor.author Kissi, F.A.
dc.contributor.author Appiah, A.A.
dc.contributor.author Penlap Beng, V.
dc.contributor.author Nyarko, A.K.
dc.date.accessioned 2019-02-12T10:54:27Z
dc.date.available 2019-02-12T10:54:27Z
dc.date.issued 2017-01
dc.identifier.other https://doi.org/10.1155/2017/2583969
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/27420
dc.description.abstract Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni. Both plant parts were found to be active against cercariae and adult worms. Within 2 h of exposure all cercariae were killed at a concentration range of 62.5-1000 μg/mL and 250-1000 μg/mL of R. vomitoria stem bark and roots, respectively. The LC50 values determined for the stem bark after 1 and 2 h of exposure were 207.4 and 61.18 μg/mL, respectively. All adult worms exposed to the concentrations range of 250-1000 μg/mL for both plant parts died within 120 h of incubation. The cytotoxic effects against HepG2 and Chang liver cell assessed using MTT assay method indicated that both plant extracts which were inhibitory to the proliferation of cell lines with IC50 > 20 μg/mL appear to be safe. This report provides the first evidence of in vitro schistosomicidal potency of R. vomitoria with the stem bark being moderately, but relatively, more active and selective against schistosome parasites. This suggests the presence of promising medicinal constituent(s). © 2017 Emmanuel Mouafo Tekwu et al. en_US
dc.language.iso en en_US
dc.publisher Journal of Parasitology Research en_US
dc.subject Anthelmintic Activities en_US
dc.subject Rauwolfia vomitoria (Apocynaceae) en_US
dc.subject Parasitic Stages en_US
dc.subject Stem Bark and Roots en_US
dc.subject Schistosoma mansoni en_US
dc.subject Cytotoxic Study en_US
dc.title In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study en_US
dc.type Article en_US


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  • Parasitology Department [253]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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