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Title: Surface marker patterns of T cells and expression of interleukin-2 receptor in measles infection
Authors: Addae, M.M.
Komada, Y.
Taniguchi, K.
Kamiya, T.
Osei-Kwasi, M.
Akanmori, B.D.
Nkrumah, F.K.
Keywords: Antigens, Surface/*metabolism
CD4-CD8 Ratio
Cell Survival
Child, Preschool
Immunity, Cellular
Lymphocyte Activation
Receptors, Interleukin-2/*metabolism
Issue Date: 1998
Publisher: Acta Paediatrica Japonica
Citation: Addae, M. M., Komada, Y., Taniguchi, K., Kamiya, T., Osei-Kwasi, M., Akanmori, B. D., & Nkrumah, F. K. (1998). Surface marker patterns of T cells and expression of interleukin-2 receptor in measles infection. Acta Paediatrica Japonica (Overseas Edition), 40(1), 7-13
Abstract: The surface marker patterns of T cells of Ghanaian children during measles infection were studied and an attempt was made to demonstrate T cell activation and viability in vitro after activation in vivo by measles virus. The frequencies of CD4+ and CD8+ naive T cells in measles patients were high while their memory T cells were remarkably reduced with no sign of proliferation even at the acute phase of the illness. The reduction of memory T cells was prolonged during the convalescent phase (2 months after onset). The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression. On simple culture, an appreciable proportion of T cells from measles patients died rapidly in contrast with only a few T cells from healthy controls doing so. The suppression of CD25 expression was still demonstrated during the convalescent phase of the disease. Taken together these results suggest unresponsiveness and activation-induced cell death of T cells during severe measles infection in Ghanaian children. Furthermore the prolonged abnormalities of T cells (i.e. decreased memory T cells and inhibition of CD25 expression during the convalescent phase) might be related to post-measles infection immunosuppressive status.
Appears in Collections:Noguchi Memorial Institute for Medical Research

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