|Title:||Surface marker patterns of T cells and expression of interleukin-2 receptor in measles infection|
|Publisher:||Acta Paediatrica Japonica|
|Citation:||Addae, M. M., Komada, Y., Taniguchi, K., Kamiya, T., Osei-Kwasi, M., Akanmori, B. D., & Nkrumah, F. K. (1998). Surface marker patterns of T cells and expression of interleukin-2 receptor in measles infection. Acta Paediatrica Japonica (Overseas Edition), 40(1), 7-13|
|Abstract:||The surface marker patterns of T cells of Ghanaian children during measles infection were studied and an attempt was made to demonstrate T cell activation and viability in vitro after activation in vivo by measles virus. The frequencies of CD4+ and CD8+ naive T cells in measles patients were high while their memory T cells were remarkably reduced with no sign of proliferation even at the acute phase of the illness. The reduction of memory T cells was prolonged during the convalescent phase (2 months after onset). The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression. On simple culture, an appreciable proportion of T cells from measles patients died rapidly in contrast with only a few T cells from healthy controls doing so. The suppression of CD25 expression was still demonstrated during the convalescent phase of the disease. Taken together these results suggest unresponsiveness and activation-induced cell death of T cells during severe measles infection in Ghanaian children. Furthermore the prolonged abnormalities of T cells (i.e. decreased memory T cells and inhibition of CD25 expression during the convalescent phase) might be related to post-measles infection immunosuppressive status.|
|Appears in Collections:||Noguchi Memorial Institute for Medical Research|
|Surface marker patterns of T cells and expression of interleukin-2 receptor in measles infection.pdf||558.3 kB||Adobe PDF||View/Open|
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