Reversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis.

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dc.contributor.author Adjei, G.O.
dc.contributor.author Adabayeri, V.M.
dc.contributor.author Annobil, S.H.
dc.date.accessioned 2019-01-11T13:45:08Z
dc.date.available 2019-01-11T13:45:08Z
dc.date.issued 2012-09
dc.identifier.other Vol. 46(3): pp 171-3
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/26778
dc.description.abstract A case of an acute reversible visual loss in a 10-year-old child who was on mefloquine prophylaxis, and was treated with artesunate-amodiaquine for an acute febrile illness diagnosed clinically as uncomplicated malaria, is reported. On admission the patient could not perceive light and had bilateral papilloedema. She was treated with dexamethasone and recovered her sight gradually over a 21-day period. There has been no previous report to our knowledge, of an association between acute visual loss and mefloquine, amodiaquine, or artesunate in the published literature, even though mefloquine is associated with blurring of vision, and antimalarials of the quinoline class have been associated with retinopathy (during long term use). While causality is difficult to ascribe in this case, it may be prudent to avoid the use of quinoline-based antimalarials for treating acute malaria in travelers taking mefloquine prophylaxis, because information on the safety of concurrent use of artemisinin combination therapies and mefloquine, or other recommended prophylactic regimens, is limited. en_US
dc.language.iso en en_US
dc.publisher Ghana medical journal en_US
dc.subject Reversible binocular visual en_US
dc.subject artesunate-amodiaquine en_US
dc.subject treatment en_US
dc.subject mefloquine chemoprophylaxis en_US
dc.title Reversible binocular visual loss in temporal association with artesunate-amodiaquine treatment in a child on mefloquine chemoprophylaxis. en_US
dc.type Article en_US


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