The promise and pitfalls of mass drug administration to control intestinal helminth infections

Show simple item record Humphries, D. Nguyen, S. Boakye, D. Wilson, M. Cappello, M. 2019-01-11T11:24:21Z 2019-01-11T11:24:21Z 2012-08
dc.identifier.other Vol. 25(5): pp 584-9
dc.identifier.other DOI: 10.1097/QCO.0b013e328357e4cf
dc.description.abstract Purpose of Review: Intestinal helminth infections continue to cause significant morbidity in resource-limited settings. Recent efforts at global control have centered on mass drug administration (MDA) of praziquantel and benzimidazole anthelminthics to reduce the prevalence and intensity of schistosomiasis and soil-transmitted nematode infections, respectively. This review summarizes progress and potential challenges associated with MDA. Recent Findings: Data from studies conducted in endemic areas show that chemotherapeutic interventions can reduce prevalence and intensity of infection with intestinal helminths, and have the potential to reduce transmission within populations. However, consistent benefits in high-risk groups, including children and pregnant women, have not been established. The long-term benefits of MDA remain to be determined, and the potential for emerging resistance to impact effectiveness have not yet been defined. CONCLUSIONS: Whereas studies evaluating MDA have shown benefit in certain populations, intensive monitoring and evaluation, as well as a commitment of resources for new drug development, are essential for long-term control or elimination of intestinal helminth infections. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. en_US
dc.language.iso en en_US
dc.publisher Current Opinion in Infectious Diseases en_US
dc.subject benzimidazoles en_US
dc.subject mass drug administration en_US
dc.subject praziquantel en_US
dc.subject schistosomiasis en_US
dc.subject soil-transmitted nematodes en_US
dc.title The promise and pitfalls of mass drug administration to control intestinal helminth infections en_US
dc.type Other en_US

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  • Parasitology Department [253]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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