Schistosome infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian Schoolchildren

Show simple item record Obeng, B.B. Amoah, A.S. Larbi, I.A. de Souza, D.K. Uh, H.-W. Fernández-Rivas, M. van Ree, R. Rodrigues, L.C. Boakye, D.A. Yazdanbakhsh, M. Hartgers, F.C. 2018-11-27T13:23:38Z 2018-11-27T13:23:38Z 2014-07
dc.identifier.other Volume 44, Issue 7, Pages 965-975
dc.description.abstract Background: Epidemiological evidence suggests that helminth infection and rural living are inversely associated with allergic disorders. Objective: The aim of the study was to investigate the effect of helminth infections and urban versus rural residence on allergy in schoolchildren from Ghana. Methods: In a cross-sectional study of 1385 children from urban-high socio-economic status (SES), urban-low SES and rural schools, associations between body mass index (BMI), allergen-specific IgE (sIgE), parasitic infections and allergy outcomes were analysed. Allergy outcomes were skin prick test (SPT) reactivity, reported current wheeze and asthma. Results: Helminth infections were found predominantly among rural subjects, and the most common were hookworm (9.9%) and Schistosoma spp (9.5%). Being overweight was highest among urban-high SES (14.6%) compared to urban-low SES (5.5%) and rural children (8.6%). The prevalence of SPT reactivity to any allergen was 18.3%, and this was highest among rural children (21.4%) followed by urban-high SES (20.2%) and urban-low SES (10.5%) children. Overall, SPT reactivity to mite (12%) was most common. Wheeze and asthma were reported by 7.9% and 8.3%, respectively. In multivariate analyses, factors associated with mite SPT were BMI (aOR 2.43, 95% CI 1.28-4.60, P = 0.007), schistosome infection (aOR 0.15, 95% CI 0.05-0.41) and mite sIgE (aOR 7.40, 95% CI 5.62-9.73, P < 0.001) but not area. However, the association between mite IgE and SPT differed by area and was strongest among urban-high SES children (aOR = 15.58, 95% CI 7.05-34.43, P < 0.001). Compared to rural, urban-low SES area was negatively associated with current wheeze (aOR 0.41, 95% CI 0.20-0.83, P = 0.013). Both mite sIgE and mite SPT were significantly associated with current wheeze and asthma. Conclusion and Clinical Relevance: Infection with schistosomes appeared to protect against mite SPT reactivity. This needs to be confirmed in future studies, preferably in a longitudinal design where schistosome infections are treated and allergic reactions reassessed. © 2014 John Wiley & Sons Ltd. en_US
dc.language.iso en en_US
dc.publisher Clinical and Experimental Allergy en_US
dc.subject Africa en_US
dc.subject Allergy en_US
dc.subject Asthma en_US
dc.subject Atopy en_US
dc.subject Body mass index en_US
dc.subject Cockroach en_US
dc.subject Helminth en_US
dc.subject Mite en_US
dc.subject Rural en_US
dc.subject Schistosoma en_US
dc.subject Urban en_US
dc.subject Wheeze en_US
dc.title Schistosome infection is negatively associated with mite atopy, but not wheeze and asthma in Ghanaian Schoolchildren en_US
dc.type Article en_US

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  • Parasitology Department [244]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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