Dynamics of the antibody response to Plasmodium falciparum infection in African children

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dc.contributor.author White, M.T.
dc.contributor.author Griffin, J.T.
dc.contributor.author Akpogheneta, O.
dc.contributor.author Conway, D.J.
dc.contributor.author Koram, K.A.
dc.contributor.author Riley, E.M.
dc.contributor.author Ghani, A.C.
dc.date.accessioned 2018-11-26T10:37:48Z
dc.date.available 2018-11-26T10:37:48Z
dc.date.issued 2014-04
dc.identifier.other DOI: 10.1093/infdis/jiu219
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/25802
dc.description.abstract Background. Acquired immune responses to malaria have widely been perceived sto be short-lived, with previously immune individuals losing immunity when they move from malaria-endemic areas. However longlived Plasmodium falciparum-specific antibody responses lasting for an individual's lifetime are frequently observed. Methods. We fit mathematical models of the dynamics of antibody titers to P. falciparum antigens from longitudinal cohort studies of African children to estimate the half-lives of circulating immunoglobulin G (IgG) antibodies and IgG antibody-secreting cells (ASCs). Results. Comparison of antibody responses in the younger Ghanaian cohort and the older Gambian cohort suggests that young children are less able to generate the long-lived ASCs necessary to maintain the circulating antibodies that may provide protection against reinfection. Antibody responses in African children can be described by a model 15 including both short-lived ASCs (half-life range, 2-10 days), which are responsible for boosting antibody titers following infection, and long-lived ASCs (half-life range, 3-9 years), which are responsible for maintaining sustained humoral responses. Conclusions. The rapid decay of antibodies following exposure to malaria and the maintenance of sustained antibody responses can be explained in terms of populations of short-lived and long-lived ASCs. © The Author 2014. en_US
dc.language.iso en en_US
dc.publisher Journal of Infectious Diseases en_US
dc.subject Antibody en_US
dc.subject Immunity en_US
dc.subject Malaria en_US
dc.subject Model en_US
dc.subject Plasmodium falciparum en_US
dc.title Dynamics of the antibody response to Plasmodium falciparum infection in African children en_US
dc.type Article en_US

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    The Epidemiology Department contributes to the mission of the institute through basic and applied epidemiological research on, but not limited to, malaria and other diseases of public health importance. It is also home to the Social Science Unit of the Institute, including the Health Support Centre for HIV/AIDS and other communicable and noncommunicable health problems.

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