Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity

Show simple item record Amoah, A.S. Obeng, B.B. Larbi, I.A. Versteeg, S.A. Aryeetey, Y. Akkerdaas, J.H. Zuidmeer, L. Lidholm, J. Fernandez-Rivas, M. Hartgers, F.C. Boakye, D.A. van Ree, R. Yazdanbakhsh, M. 2018-11-15T12:11:16Z 2018-11-15T12:11:16Z 2013-06-12
dc.description Article en_US
dc.description.abstract The prevalence of peanut allergy has increased in developed countries, but little is known about developing countries with high peanut consumption and widespread parasitic infections. Objective: We sought to investigate peanut allergy in Ghana. Methods: In a cross-sectional survey among Ghanaian schoolchildren (n 5 1604), data were collected on reported adverse reactions to peanut, peanut sensitization (serum specific IgE and skin reactivity), consumption patterns, and parasitic infections. In a subset (n 5 43) IgE against Ara h 1, 2, 3, and 9 as well as cross-reactive carbohydrate determinants (CCDs) was measured by using ImmunoCAP. Cross-reactivity and biological activity were investigated by means of ImmunoCAP inhibition and basophil histamine release, respectively. Results: Adverse reactions to peanut were reported in 1.5%, skin prick test reactivity in 2.0%, and IgE sensitization (>0.35 kU/L) in 17.5% of participants. Moreover, 92.4% of those IgE sensitized to peanut (>0.35 kU/L) had negative peanut skin prick test responses. Schistosoma haematobium infection was positively associated with IgE sensitization (adjusted odds ratio, 2.29; 95% CI, 1.37-3.86). In the subset IgE titers to Ara h 1, 2, 3, and 9 were low (<1.3 kU/L), except for 6 moderately strong reactions to Ara h 9. IgE against peanut was strongly correlated with IgE against CCDs (r 5 0.89, P < .0001) and could be almost completely inhibited by CCDs, as well as S haematobium soluble egg antigen. Moreover, IgE to peanut showed poor biological activity. Conclusions: Parasite-induced IgE against CCDs might account largely for high IgE levels to peanut in our study population of Ghanaian schoolchildren. No evidence of IgE-mediated peanut allergy was found. (J Allergy Clin Immunol 2013;132:639-47.) en_US
dc.description.sponsorship EuroPrevall (FOOD-CT-2005-514000), GLOFAL (FOOD-CT-2005- 517812), and the Wellcome Trust (075791/Z/04/Z). en_US
dc.language.iso en en_US
dc.publisher American Academy of Allergy, Asthma & Immunology en_US
dc.subject Peanut allergy en_US
dc.subject skin prick testing en_US
dc.subject IgE en_US
dc.subject Sub-Saharan Africa en_US
dc.subject IgE cross-reactivity en_US
dc.subject cross-reactive carbohydrate determinants en_US
dc.subject helminth infections en_US
dc.subject basophil histamine release en_US
dc.subject EuroPrevall en_US
dc.title Peanut-specific IgE antibodies in asymptomatic Ghanaian children possibly caused by carbohydrate determinant cross-reactivity en_US
dc.type Article en_US

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  • Parasitology Department [247]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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