Plasma levels of some coagulation parameters in Steady State HBSC disease patients

Show simple item record Ajuwon, M.D. Olayemi, E. Benneh, A.A. 2018-11-08T09:21:23Z 2018-11-08T09:21:23Z 2014-11
dc.identifier.other DOI: 10.11604/pamj.2014.19.289.4451
dc.description.abstract Introduction: sickle cell disease is a collection of autosomal recessive genetic disorders. It includes homozygous HbSS and double heterozygote combinations such as HbSC. Central and West Africa bears a significant burden of HbSC disease.Methods: prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen concentration (FC) and platelet count (PC) weredetermined in 41HbSC and HbSS patientsin steady state along with 40 apparently healthy HbAA controls. One way ANOVA test was used to compare means;p values < 0.05 were considered statistically significant.Results: there was no significant difference in mean PT for the study groups (p = 0.192). Mean PC was highest in HbSS patients: 445.7 +/- 128.3 X 10 9/ L compared to HbSC: 330.0 +/- 97.7 X 10 9/ L andHbAA:245 +/- 77.7 X 10 9/ L (p= 0.000).Mean APTT was 28.1 +/- 3.8 seconds in controls,24.1+/- 66 seconds in HbSS patients and 21.8 +/- 3.8 seconds in HbSC patients (p = 0.000). Mean FCin HbSS was 1.6 +/- 0.7 g/L , 3.2 +/- 0.6 g/L in HbSC and 2.9 +/- 0.4 g/L in HbAA (p =0.000).Conclusion: a significant difference exists in PC, APTT and FC in HbSC patients compared to HbSS patients and HbAA controls. Elevated FC and shortened APTT may play a role in complications more characteristic of HbSC such as retinopathy and osteonecrosis. These suggestHbSC is not merely a milder form of HbSS; both diseases should be seen as different entities with regards to approaches for management. © 2014, Mauryne Debola Ajuwon et al. en_US
dc.language.iso en en_US
dc.publisher Pan African Medical Journal en_US
dc.subject Coagulation parameters en_US
dc.subject Ghana en_US
dc.subject HbSC disease en_US
dc.subject Steady State en_US
dc.title Plasma levels of some coagulation parameters in Steady State HBSC disease patients en_US
dc.type Article en_US

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