Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula

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dc.contributor.author Annan, K.
dc.contributor.author Ekuadzi, E.
dc.contributor.author Asare, C.
dc.contributor.author Sarpong, K.
dc.contributor.author Pistorius, D.
dc.contributor.author Oberer, L.
dc.contributor.author Gyan, B.A.
dc.contributor.author Ofori, M.
dc.date.accessioned 2018-11-05T12:28:15Z
dc.date.available 2018-11-05T12:28:15Z
dc.date.issued 2014-11
dc.identifier.other https://doi.org/10.1016/j.phytol.2014.10.028
dc.identifier.other Volume 11,Pages 28-31
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/25275
dc.description.abstract Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM. © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. en_US
dc.language.iso en en_US
dc.publisher Phytochemistry Letters en_US
dc.subject Antiplasmodial en_US
dc.subject Bisclerodane imide en_US
dc.subject Clerodane en_US
dc.subject Diterpenes en_US
dc.subject Polyalthia longifolia en_US
dc.title Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula en_US
dc.type Article en_US


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  • Immunology Department [184]
    The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

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