Implantable polymer/metal thin film structures for the localized treatment of cancer by Joule heating

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dc.contributor.author Kan-Dapaah, K.
dc.contributor.author Rahbar, N.
dc.contributor.author Theriault, C.
dc.contributor.author Soboyejo, W.
dc.date.accessioned 2018-11-05T11:35:16Z
dc.date.available 2018-11-05T11:35:16Z
dc.date.issued 2015-04
dc.identifier.issn 218979
dc.identifier.other Vol. 117(16):165301
dc.identifier.other doi:10.1063/1.4918271
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/25265
dc.description.abstract This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The predictions are also compared to prior results from in vitro studies and relevant in vivo studies in the literature. The implications of the results are discussed for the potential application of polymer/metal thin film structures in hyperthermic treatment of cancer. © 2015 AIP Publishing LLC. en_US
dc.language.iso en en_US
dc.publisher Journal of Applied Physics en_US
dc.subject FEM en_US
dc.subject Implantable polymer en_US
dc.subject Breast cancer en_US
dc.subject heating en_US
dc.title Implantable polymer/metal thin film structures for the localized treatment of cancer by Joule heating en_US
dc.type Article en_US


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