Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5′-methylthioinosine from a Ghanaian Micromonospora sp. K310

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dc.contributor.author Kyeremeh, K.
dc.contributor.author Acquah, K.S.
dc.contributor.author Sazak, A.
dc.contributor.author Houssen, W.
dc.contributor.author Tabudravu, J.
dc.contributor.author Deng, H.
dc.contributor.author Jaspars, M.
dc.date.accessioned 2018-11-02T17:52:11Z
dc.date.available 2018-11-02T17:52:11Z
dc.date.issued 2014
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/25227
dc.description.abstract A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin ( 2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes. © 2014 by the authors; licensee MDPI. en_US
dc.language.iso en en_US
dc.publisher Marine Drugs en_US
dc.subject Macrolactam en_US
dc.subject Mangroves en_US
dc.subject Micromonospora en_US
dc.subject Tautomer en_US
dc.subject Tetramic acid en_US
dc.title Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5′-methylthioinosine from a Ghanaian Micromonospora sp. K310 en_US
dc.type Article en_US


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