Human pegivirus (HPgV) infection in Ghanaians co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV)

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dc.contributor.author N’Guessan, K.F.
dc.contributor.author Boyce, C.
dc.contributor.author Kwara, A.
dc.contributor.author Archampong, T.N.A.
dc.contributor.author Lartey, M.
dc.contributor.author Sagoe, K.W.
dc.contributor.author Kenu, E.
dc.contributor.author Obo-Akwa, A.
dc.contributor.author Blackard, J.T.
dc.date.accessioned 2018-09-20T13:46:24Z
dc.date.available 2018-09-20T13:46:24Z
dc.date.issued 2018
dc.identifier.other doi:10.1007/s11262-018-1555-2
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/24300
dc.description.abstract Human pegivirus (HPgV) is a positive single-stranded RNA virus in the Flaviviridae family. Phylogenetic analysis reveals the presence of multiple HPgV genotypes with distinct geographic locations. HPgV is of interest because of its potential beneficial impact on HIV disease progression. Despite this, the effects of HPgV in the context of other viral infections, such as hepatitis B virus (HBV), are poorly understood, and data from resource-limited settings are scarce. Therefore, we conducted a cross-sectional analysis of HPgV in HIV/HBV co-infected patients in Ghana. Sera from 100 HIV/HBV co-infected individuals were evaluated for HPgV RNA, and the genotype determined by sequencing the 5′ untranslated region. HPgV RNA was detected in 27 samples (27%). Of these, 26 were genotyped successfully with 23 belonging to HPgV genotype 1 and 3 belonging to HPgV genotype 2. The presence of HPgV RNA had no statistically significant impact on CD4 cell count or HBV DNA titers in the HIV/HBV co-infected patients. However, there was a trend towards decreased HBV DNA levels in HPgV RNA-positive patients with CD4 cell count < 200 (p = 0.0626). HPgV co-infection is common in Ghana. The effect of HPgV on HIV or HBV disease among HIV/HBV co-infected patients was minimal. However, decreased HBV DNA levels in HPgV RNA-positive patients with low CD4 cell counts highlight the need for prospective studies of HPgV in HIV and hepatitis co-infected patients, especially in those with advanced HIV disease, to study further the effects of HPgV on liver disease. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. en_US
dc.language.iso en en_US
dc.publisher Springer New York LLC en_US
dc.subject Africa en_US
dc.subject GB virus C (GBV-C) en_US
dc.subject Ghana en_US
dc.subject Hepatitis B virus (HBV) en_US
dc.subject Pegivirus (HPgV) en_US
dc.title Human pegivirus (HPgV) infection in Ghanaians co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) en_US
dc.type Article en_US


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