Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana

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dc.contributor.author Lamelas, A.
dc.contributor.author Ampah, K.A.
dc.contributor.author Aboagye, S.
dc.contributor.author Kerber, S.
dc.contributor.author Danso, E.
dc.contributor.author Asante-Poku, A.
dc.contributor.author Asare, P.
dc.contributor.author Parkhill, J.
dc.contributor.author Harris, S.R.
dc.contributor.author Pluschke, G.
dc.contributor.author Yeboah-Manu, D.
dc.contributor.author Röltgen, K.
dc.date.accessioned 2017-10-30T13:22:54Z
dc.date.available 2017-10-30T13:22:54Z
dc.date.issued 2016
dc.identifier.issn 19352727
dc.identifier.other 10.1371/journal.pntd.0004856
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/22323
dc.description.abstract In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely related isolates and a striking association between genotype and geographical origin of the patients. Here, we compared whole genome sequences of five M. ulcerans strains isolated in 2004 or 2013 from BU lesions of four residents of the Offin river valley with 48 strains isolated between 2002 and 2005 from BU lesions of individuals residing in the Densu river valley of Ghana. While all M. ulcerans isolates from the Densu river valley belonged to the same clonal complex, members of two distinct clonal complexes were found in the Offin river valley over space and time. The Offin strains were closely related to genotypes from either the Densu region or from the Asante Akim North district of Ghana. These results point towards an occasional involvement of a mobile reservoir in the transmission of M. ulcerans, enabling the spread of bacteria across different regions. © 2016 Lamelas et al. en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.title Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana en_US
dc.type Article en_US


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    The Epidemiology Department contributes to the mission of the institute through basic and applied epidemiological research on, but not limited to, malaria and other diseases of public health importance. It is also home to the Social Science Unit of the Institute, including the Health Support Centre for HIV/AIDS and other communicable and noncommunicable health problems.

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