Pulmonary tuberculosis: virulence of Mycobacterium africanum and relevance in HIV co-infection

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dc.contributor.author Meyer, C.G.
dc.contributor.author Scarisbrick, G.
dc.contributor.author Niemann, S.
dc.contributor.author Browne, E.N.L.
dc.contributor.author Chinbuah, M.A.
dc.contributor.author Gyapong, J.O.
dc.contributor.author Osei, I.
dc.contributor.author Owusu-Dabo, E.
dc.contributor.author Kubica, T.
dc.contributor.author Rüsch-Gerdes, S.
dc.contributor.author Thye, T.
dc.contributor.author Horstmann, R.D.
dc.date.accessioned 2012-09-13T14:54:12Z
dc.date.accessioned 2017-10-16T12:21:19Z
dc.date.available 2012-09-13T14:54:12Z
dc.date.available 2017-10-16T12:21:19Z
dc.date.issued 2008
dc.identifier.citation Tuberculosis (2008) 88, 482e489 en_US
dc.identifier.uri http://197.255.68.203/handle/123456789/1855
dc.description.abstract Although Mycobacterium africanum is being isolated in a significant proportion of cases of pulmonary tuberculosis in West Africa, its pathogenic potential remains a matter of discussion. Recent reports leave the question of whether M. africanum causes more severe pathology than M. tuberculosis or resembles opportunistic pathogens and might gain importance in the course of the HIV pandemic. Patients with pulmonary tuberculosis associated with M. africanum(nZ556) and M. tuberculosis (nZ1350) were studied in Ghana, West Africa, and compared regarding self-reported signs and symptoms, chest radiography, HIV status, mycobacterial drug resistance and mycobacterial clustering as determined by spoligotyping and IS6110 fingerprints. The rate of M. africanum infections was similar in HIV-positive (27%) and HIV-negative (30%) patients. M. africanum clustered less than M. tuberculosis (21% vs 79%; OR, 0.38; 95% CI, 0.3e0.5; p < 0.001) corresponding to its lower prevalence (29% vs 70%). Clinically and radiographically, no significant differences were found except that M. africanum caused lower-lobe disease less frequently than M. tuberculosis (OR, 0.39; 95% CI, 0.2e0.7; pcZ0.01), whereby this association applied to HIV-negative patients only. No difference in virulence, as assessed by the severity of radiological presentation, was found when the two M. africanum subtypes West African 1 andWest African 2 were compared. In the population studied, M. africanum closely resembled M. tuberculosis in pathology and cannot be considered an opportunistic pathogen. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Tuberculosis en_US
dc.subject M. africanum en_US
dc.subject Opportunist en_US
dc.subject Virulence en_US
dc.title Pulmonary tuberculosis: virulence of Mycobacterium africanum and relevance in HIV co-infection en_US
dc.type Article en_US


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