Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1855
Title: Pulmonary tuberculosis: virulence of Mycobacterium africanum and relevance in HIV co-infection
Authors: Meyer, C.G.
Scarisbrick, G.
Niemann, S.
Browne, E.N.L.
Chinbuah, M.A.
Gyapong, J.O.
Osei, I.
Owusu-Dabo, E.
Kubica, T.
Rüsch-Gerdes, S.
Thye, T.
Horstmann, R.D.
Keywords: Tuberculosis
M. africanum
Opportunist
Virulence
Issue Date: 2008
Publisher: Elsevier
Citation: Tuberculosis (2008) 88, 482e489
Abstract: Although Mycobacterium africanum is being isolated in a significant proportion of cases of pulmonary tuberculosis in West Africa, its pathogenic potential remains a matter of discussion. Recent reports leave the question of whether M. africanum causes more severe pathology than M. tuberculosis or resembles opportunistic pathogens and might gain importance in the course of the HIV pandemic. Patients with pulmonary tuberculosis associated with M. africanum(nZ556) and M. tuberculosis (nZ1350) were studied in Ghana, West Africa, and compared regarding self-reported signs and symptoms, chest radiography, HIV status, mycobacterial drug resistance and mycobacterial clustering as determined by spoligotyping and IS6110 fingerprints. The rate of M. africanum infections was similar in HIV-positive (27%) and HIV-negative (30%) patients. M. africanum clustered less than M. tuberculosis (21% vs 79%; OR, 0.38; 95% CI, 0.3e0.5; p < 0.001) corresponding to its lower prevalence (29% vs 70%). Clinically and radiographically, no significant differences were found except that M. africanum caused lower-lobe disease less frequently than M. tuberculosis (OR, 0.39; 95% CI, 0.2e0.7; pcZ0.01), whereby this association applied to HIV-negative patients only. No difference in virulence, as assessed by the severity of radiological presentation, was found when the two M. africanum subtypes West African 1 andWest African 2 were compared. In the population studied, M. africanum closely resembled M. tuberculosis in pathology and cannot be considered an opportunistic pathogen.
URI: http://hdl.handle.net/123456789/1855
Appears in Collections:School of Public Health 9

Files in This Item:
There are no files associated with this item.


Items in UGSpace are protected by copyright, with all rights reserved, unless otherwise indicated.