Common variants at 11p13 are associated with susceptibility to tuberculosis

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dc.contributor.author Thye, T.
dc.contributor.author Owusu-Dabo, E.
dc.contributor.author Vannberg, F.O.
dc.contributor.author van Crevel, R.
dc.contributor.author Curtis, J.
dc.contributor.author Sahiratmadja, E.
dc.contributor.author Balabanova, Y.
dc.contributor.author Ehmen, C.
dc.contributor.author Muntau, B.
dc.contributor.author Ruge, G.
dc.contributor.author Sievertsen, J.
dc.contributor.author Gyapong, J.
dc.contributor.author Nikolayevskyy, V.
dc.contributor.author Hill, P.C.
dc.contributor.author Sirugo, G.
dc.contributor.author Drobniewski, F.
dc.contributor.author van de Vosse, E.
dc.contributor.author Newport, M.
dc.contributor.author Alisjahbana, B.
dc.contributor.author Nejentsev, S.
dc.contributor.author Ottenhoff, T.H.
dc.contributor.author Hill, A.V.
dc.contributor.author Horstmann, R.D.
dc.contributor.author Meyer, C.G.
dc.date.accessioned 2012-09-13T11:34:38Z
dc.date.accessioned 2017-10-16T12:22:23Z
dc.date.available 2012-09-13T11:34:38Z
dc.date.available 2017-10-16T12:22:23Z
dc.date.issued 2012
dc.identifier.citation Nature Genetics. 2012 Feb 5. doi: 10.1038/ng.1080 en_US
dc.identifier.uri http://197.255.68.203/handle/123456789/1838
dc.description.abstract After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10−9). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10−11. en_US
dc.language.iso en en_US
dc.publisher Nature Genetics en_US
dc.subject Tuberculosis en_US
dc.title Common variants at 11p13 are associated with susceptibility to tuberculosis en_US
dc.type Article en_US


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