Abstract:
In this study we investigate the cytotoxicity of de-starched cassava fibre granules and fine powder using human peripheral blood mononuclear cells (PBMC) and examine changes in the composition of Simulated Body Fluid(SBF) resulting from immersion of cassava fibre samples. The purpose of the study was to characterise cassava fibre for possible biomaterial applications. Preliminary results indicate insignificant cytotoxic effects on PBMCs with cassava sample concentrations of 0.1g/ml, 0.025g/ml and 0.00625g/ml. Additionally there was little or no significant change in Na, K, Mg, Cl, Ca, Mn, and Cu concentrations upon immersion in SBF as observed over a one week period at a temperature of 37°C. These initial results suggest cassava fibre may be considered for biomaterial applications following more extensive characterisation.
