Responses to malarial antigens are altered in helminth-infected children

Show simple item record Hartgers, F.C. Obeng, B.B. Kruize, Y.C. Dijkhuis, A. McCall, M. Sauerwein, R.W. Luty, A.J. Boakye, D.A. Yazdanbakhsh, M. 2012-05-28T11:11:47Z 2017-10-16T12:59:03Z 2012-05-28T11:11:47Z 2017-10-16T12:59:03Z 2009
dc.identifier.citation Journal of Infectious Diseases 199(10): 1528-35 en_US
dc.description.abstract Malaria and helminth infections often coincide in the same tropical regions. Studies of the consequences of helminth and malaria coinfection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. In this study, we investigated the antimalarial immune responses of Ghanaian children living in a rural area with a high prevalence of both helminth infection and Plasmodium falciparum infection. Whole blood specimens were cultured with P. falciparum-infected red blood cells (iRBCs), and pro- and anti-inflammatory cytokines and immune regulatory molecules were measured. In response to iRBCs, levels of interleukin (IL)-10, but not tumor necrosis factor-alpha,were higher in samples from helminth-infected children than in those from uninfected children, as was expression of the regulatory molecules suppressor of cytokine signaling (SOCS)-3, Foxp3, and programmed death (PD)-1. Furthermore, a significant correlation was found between SOCS-3 gene expression and IL-10 production. These results indicate that the presence of helminth infection modulates the immune response to malarial parasites, making it more anti-inflammatory. en_US
dc.language.iso en en_US
dc.publisher Journal of Infectious Diseases en_US
dc.title Responses to malarial antigens are altered in helminth-infected children en_US
dc.type Article en_US

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  • Parasitology Department [244]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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