Possible adverse effect of high δ-alpha-tocopherol intake on hepatic iron overload: enhanced production of Vitamin C and the genotoxin, 8-hydroxy-2’-dexyguanosine

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dc.contributor.author Nortey, E.N.N.
dc.contributor.author Asare, A.G.
dc.contributor.author Ntobin, B.
dc.contributor.author Kew, M.C.
dc.contributor.author Kahler-Venter, P.
dc.date.accessioned 2012-05-12T15:57:44Z
dc.date.accessioned 2017-10-14T12:21:28Z
dc.date.available 2012-05-12T15:57:44Z
dc.date.available 2017-10-14T12:21:28Z
dc.date.issued 2010
dc.identifier.uri http://197.255.68.203/handle/123456789/1325
dc.description.abstract Excess hepatic iron generates reactive oxygen species that result in oxidative stress and oxidative damage to the layer. Vitamins have hitherto been considered to be a possible remedy. The aim of this study was to determine if high doses of δ-a-tocopherol supplementation in iron overload would ameltorate the oxidative stress. Four groups of 20 males Wistar albino rats were studied: group 1 (control) was fed normal diet, group 2 (Fe) 0.75% Ferrocene iron, group 3 (FV gp) 0.75% Ferrocene/δ-a-tocopherol (10x RDA), group 4 (V gp) normal diet/δ-a-tocopherol. After 12 months, serum iron, reduced glutathione, catalase, Vitamin C., Oxygen Radical Absorbance Capacity, lipid peroxidation, 8-hydroxy-2’ dexyguanosine (8-OHdG), aspartate transaminase (AST), and alanine transaminase (ALT) were measured. Vitamin C levels were F gp=5.85 ± 0.13 (µmol/l) (p<0.05). 8-hydroxy 2’-dexyguanosine levels were F gp – 143.6 ± 6.4; FV gp – 179.2 ± 18.2 (ng/ml) (p,0.05). Oxidative liver damage, as determined by serum AST and ALT levels, was not attenuated by a-tocopherol. A positive correlation existed between vitamin C and 8-OHdg, suggesting possible a-tocopherol toxicity. en_US
dc.language.iso en en_US
dc.publisher Toxicology Mechanisms and Methods 20(2): 96-104 en_US
dc.subject a-Tocopherol en_US
dc.subject antioxidants en_US
dc.subject 8-hydroxy-2’-dexyguanosine en_US
dc.subject iron overload en_US
dc.title Possible adverse effect of high δ-alpha-tocopherol intake on hepatic iron overload: enhanced production of Vitamin C and the genotoxin, 8-hydroxy-2’-dexyguanosine en_US
dc.type Article en_US


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