Mefloquine (MQ) single dose 20 mg/kg treatment of falciparum malaria was evaluated in 186 children of 6-24 months of age in northern Ghana

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dc.contributor.author Fryauff, D.J.
dc.contributor.author Owusu-Agyei, S.
dc.contributor.author Utz, G.
dc.contributor.author Baird, J.K.
dc.contributor.author Koram, K.A.
dc.contributor.author Binka, F.
dc.contributor.author Nkrumah, F.
dc.contributor.author Hoffman, S.L.
dc.date.accessioned 2012-05-03T15:41:33Z
dc.date.accessioned 2017-10-16T13:10:26Z
dc.date.available 2012-05-03T15:41:33Z
dc.date.available 2017-10-16T13:10:26Z
dc.date.issued 2007
dc.identifier.uri http://197.255.68.203/handle/123456789/1017
dc.description.abstract There were 15 RII/RIII-type parasitologic failures, all with Day 2 MQ blood levels significantly lower than children whose parasitemias cleared before Day 7 and remained clear through 28 days. Predictors of RII/RIII parasitologic response were vomiting after MQ dosing, Day 2 MQ levels < 500 ng/mL, and undetectable Day 2 levels of the carboxymefloquine metabolite. There were 50 cases of delayed RI parasitologic failure, but 71% of these cases had undetectable Day 28 blood levels of MQ and drug levels in the remaining 29% ranged below the 620 ng/mL level that suppresses MQ sensitive strains of P. falciparum. Drug levels among infants that tolerated MQ well were not associated with age, weight, hemoglobin, parasitemia, and pre-existing symptoms of vomiting or diarrhea. An observed recurrent parasitemia of 34,400 trophozoites/microL against a MQ blood concentration of 550 ng/mL was taken as indication of tolerance to suppressive levels of the drug at this location. en_US
dc.language.iso en en_US
dc.publisher American Journal of Tropical Medicine and Hygiene 76(2): 224-31 en_US
dc.title Mefloquine (MQ) single dose 20 mg/kg treatment of falciparum malaria was evaluated in 186 children of 6-24 months of age in northern Ghana en_US
dc.type Article en_US


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  • Epidemiology Department [262]
    The Epidemiology Department contributes to the mission of the institute through basic and applied epidemiological research on, but not limited to, malaria and other diseases of public health importance. It is also home to the Social Science Unit of the Institute, including the Health Support Centre for HIV/AIDS and other communicable and noncommunicable health problems.

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