Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1017
Title: Mefloquine (MQ) single dose 20 mg/kg treatment of falciparum malaria was evaluated in 186 children of 6-24 months of age in northern Ghana
Authors: Fryauff, D.J.
Owusu-Agyei, S.
Utz, G.
Baird, J.K.
Koram, K.A.
Binka, F.
Nkrumah, F.
Hoffman, S.L.
Issue Date: 2007
Publisher: American Journal of Tropical Medicine and Hygiene 76(2): 224-31
Abstract: There were 15 RII/RIII-type parasitologic failures, all with Day 2 MQ blood levels significantly lower than children whose parasitemias cleared before Day 7 and remained clear through 28 days. Predictors of RII/RIII parasitologic response were vomiting after MQ dosing, Day 2 MQ levels < 500 ng/mL, and undetectable Day 2 levels of the carboxymefloquine metabolite. There were 50 cases of delayed RI parasitologic failure, but 71% of these cases had undetectable Day 28 blood levels of MQ and drug levels in the remaining 29% ranged below the 620 ng/mL level that suppresses MQ sensitive strains of P. falciparum. Drug levels among infants that tolerated MQ well were not associated with age, weight, hemoglobin, parasitemia, and pre-existing symptoms of vomiting or diarrhea. An observed recurrent parasitemia of 34,400 trophozoites/microL against a MQ blood concentration of 550 ng/mL was taken as indication of tolerance to suppressive levels of the drug at this location.
URI: http://hdl.handle.net/123456789/1017
Appears in Collections:Noguchi Memorial Institute for Medical Research

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