Browsing by Author "Kwiatkowski, D.P."

Browsing by Author "Kwiatkowski, D.P."

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  • Auburn, S.; Diakite, M.; Fry, A.E.; Ghansah, A.; Campino, S.; Richardson, A.; Jallow, M.; Sisay-Joof, F.; Pinder, M.; Griffiths, M.J.; Peshu, N.; William, T.N.; Marsh, K.; Molyneux, M.E.; Taylor, T.E.; Koram, K.A.; Oduro, A.R.; Rogers, W.O.; Rockett, K.A.; Halder, K.; Kwiatkowski, D.P. (2008)
    Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria parasite at a cellular level. Obstruction of signal transduction via the erythrocyte G-alpha-s ...
  • Jallow, M.; Teo, Y.Y.; Small, K. S.; Koram, K.A.; Deloukas, P.; Clark, T.G.; Kivinen, K.; Bojang, K.A.; Conway, D.J.; Pinder, M.; Sirugo, G.; Sisay-Joof, F.; Usen, S.; Auburn, S.; Bumpstead, S.J.; Campino, S.; Coffey, A.; Dunham, A.; Fry, A.E.; Green, A.; Gwilliam, R.; Hurt, S.E.; Inouye, M.; Jeffreys, A.E.; Mendy, A.; Palotie, A.; Potter, S.; Ragoussis, J.; Rogers, J.; Rowlands, K.; Somaskantharajah, E.; Whittaker, P.; Wilson, M.; Kwiatkowski, D.P. (2009-06)
    We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We ...
  • Ghansah, A.; Rockett, K.A.; Clark, T. G.; Wilson, M.D.; Koram, K. A.; Oduro, A. R.; Amenga-Etego, L.; Anyorigiya, T.; Hodgson, A.; Milligan, P.; Rogers, W.O.; Kwiatkowski, D.P. (2012-04)
    Background: Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist ...
  • Fry, A.E.; Ghansa, A.; Small, K. S.; Palma, A.; Auburn, S.; Diakite, M.; Green, A.; Campino, S.; Teo, Y.Y.; Clarke, T.G.; Jeffreys, A.E.; Wilson, J.; Jallow, M.; Sisay-Joof, F.; Pinder, M.; Griffiths, M.J.; Peshu, N.; William, T.N.; Newton, C.R.; Marsh, K.; Molyneux, M.E.; Taylor, T.E.; Koram, K.A.; Oduro, A.R.; Roger, W.O.; Rockett, K.A.; Sabeti, P.C.; Kwiatkowski, D.P. (2009)
    The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated ...

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